Control of an outbreak of infection with the hypervirulent clostridium difficile B1 strain in a university hospital using a comprehensive "bundle" approach
- Muto, C.A.
- Blank, M.K.
- Marsh, J.W.
- Vergis, E.N.
- O'Leary, M.M.
- Shutt, K.A.
- Pasculle, A.W.
- Pokrywka, M.
- Garcia, J.G.
- Posey, K.
- Roberts, T.L.
- Potoski, B.A.
- Blank, G.E.
- Simmons, R.L.
- Veldkamp, P.
- Harrison, L.H.
- Paterson, D.L.
DOIAbstract
Background. In June 2000, the hospital-acquired Clostridium difficile (CD) infection rate in our hospital (University of Pittsburgh Medical Center-Presbyterian, Pittsburgh, PA) increased to 10.4 infections per 1000 hospital discharges (HDs); the annual rate increased from 2.7 infections per 1000 HDs to 7.2 infections per 1000 HDs and was accompanied by an increase in the frequency of severe outcomes. Forty-seven (51%) of 92 HA CD isolates in 2001 were identified as the "epidemic BI strain." A comprehensive CD infection control "bundle" was implemented to control the outbreak of CD infection
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